Evaluation of the Acute Toxicity of Aqueous Extracts from Two Species of Corchorus Genus: Corchorus aestuans L. and Corchorus olitorius L. (Malvaceae)
Asian Research Journal of Agriculture,
Page 245-253
DOI:
10.9734/arja/2022/v15i4375
Abstract
Aims: Corchorus aestuans and Corchorus olitorius are two species of the genus commonly mentioned in Côte d'Ivoire as medicinal plants whose leaves decoctions are used to treat various diseases. To avoid cases of intoxication in traditional treatments, this study evaluates the acute toxicity of these plant species by having mice gorge on increasing doses of crude aqueous extract.
Place and Duration of Study: This study was carried out in the Pharmacognosy Laboratory of Félix HOUPHOUËT-BOIGNY University (Côte d'Ivoire), between march 2016 and september 2016.
Methodology: To assess the acute toxicity of the two extracts, we used 110 mice of SWISS breed. These animals aged four to six weeks were of both sexes (55 mice for each sex) and weighed between 13 and 26 g. Before the manipulations, the animals were fasted 12 hours before being divided into 11 batches of 10 mice receiving extract 1 (Corchorus aestuans) and extract 2 (Corchorus olitorius). We observed the effets of each phytomedecine on mice in different batches.
Results: Aqueous extracts of Corchorus aestuans and Corchorus olitorius (Malvaceae), administered orally, exert a dose-response effect. Concerning toxicity activities, Corchorus olitorius is not toxic. However, Corchorus aestuans is slightly toxic in the conditions of this study. The dose which kills half of the animals (LD 50 ) is 3999.93 mg/kg by oral voice (vo). This dose is the threshold of toxicity of the plant in the conditions of this study. Fortunately, this toxicity threshold is not accessible in therapy. The phytomedicine, in the conditions of use in traditional medicine in Côte d'Ivoire, is not toxic.
Conclusion: The two plant species thus offer an interesting margin of safety, which is reassuring as to the use of the decoction, for the treatment of various pathologies.
Keywords:
- Corchorus olitorius
- Corchorus aestuans
- toxicity
- phytomedicine
- Côte d’Ivoire
How to Cite
References
N'guessan K. Medicinal plants and traditional medical practices among the Abbey and Krobou peoples of the Department of Agboville (Ivory Coast). State Doctorate Thesis in Natural Sciences, Ethnobotany Specialty, University of Cocody -Abidjan, (Ivory Coast), UFR Biosciences, Botany Laboratory. 2008;235.
TA Bi H. Ethnobotanical, phytochemical and pharmacodynamic studies of some species of the genus Corchorus L., listed in Côte d'Ivoire. Unique doctoral thesis, UFR Biosciences, Félix Houphouet University Boigtny d' Abidjan. 2017;142.
Ta Bi IH, Bomisso L, Assa R, N'guessan K, Ake S. Ethnobotanical study of some species of the genus Corchorus encountered in Côte d'Ivoire. European Scientific Journal. 2016;12:412 -431.
Mbaye MS. Contribution to the biosystematic study of the genus Corchorus L. (Tiliacea) in Senegal. Doctoral thesis, Cheikh Anta Diop University of Dakar. 2002;134.
Osawaru M, Ogwu M, Chime AO, Amorighoye A. Morphological and evaluation and protein profiling of three accessions of Nigerian Corchorus linn. Species. bayero. Journal of Pure and Applied Sciences. 2012;5:26 -32.
TA BI H. Ethnobotanical, phytochemical and pharmacodynamic studies of some species of the genus Corchorus L., recorded in Côte d'Ivoire. Unique doctoral thesis , UFR Biosciences, Félix Houphouet University Boigtny d'Abidjan. 2017;142.
Hodge HC, Sterner JH. Determination of substances acute toxicity by LDB50B. Bitter. Industrial Hyg . Assoc. 1943;10:93.
APG IV. An update of the Angiosperm Phylogeny Group classification for the orders and families of flowering plants: APG III. Botanical Journal of the Linnean Society. 2016;161:105-121.
AKE-ASSI L. Flora of the Ivory Coast: Systematic, biogeographical and ecological catalogue. Boissiera, Conservatory and Botanical Garden of Geneva. 2002;401.
Ake -Assi E. Plants with decorative potential in the flora of southern Côte d'Ivoire: taxonomic and ethnobotanical studies and domestication of Thunbergia atacorensis (Acanthaceae), a newly introduced species. State Doctorate Thesis in Natural Sciences, Ethnobotany Specialty, Félix Houphouet University Boigtny d'Abidjan, (Ivory Coast), UFR Biosciences, Botany Laboratory. 2015; 219.
N'guessan K, Soro K, Coulibaly K. Evaluation of the toxicity of chrysophyllum cainito in mice, B Ioterre , Rev. Inter. Sci . Earth. 2011;Flight. 11.
Ake-Assi E, N’guessan, Kouassi A. Evaluation of the acute toxicity of the aqueous extract of the leaves of thunbergia atacorensis, a new species. European Scientific Journal. 2015;11(27): 92-100.
Karber C, Brehrens B. Wie is reihenversuche fur biologische auswertungen am zweckmässigsten anzuordnen? Arch. exp. Path. Pharm. 1935;177:379-388.
Tra BI FH, Irie GM, N'gaman KCC, Mohou CHB. Study of some therapeutic plants used in the treatment of arterial hypertension and diabetes: two emerging diseases in Côte d'Ivoire. Science & Nature. 2008;5(1):39-48.
N'guessan K, Kadja B, Zihiri GN, Traore D, Ake-Assi L. Phytochemical screening of some Ivorian medicinal plants used in Krobou country (Agboville, Ivory Coast). Science and Nature. 2009;6(1):1-15.
Belemtougri RG, Mounanga CN, Ouédraogo Y, Sawadogo L. Effect of total aqueous extract of Lantana camara L. (Verbenaceae) on blood pressure in rabbits. Review of Medicines and African Pharmacopoeias. 2001;15:3-14.
N'guessan K, Fofie Y, Coulibaly K, Kone D. Evaluation of the acute toxicity of Boerhavia diffusa in mice. African Agronomy. 2012;24(1):1 – 6.
N'guessan K, Fofie Nby, Zihiri GN Effect of aqueous extract of Terminalia catappa leaves on the glycemia of rabbits. International Journal of Applied Pharmaceutical Science. 2011;1(8): 59.
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